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Because EBI is expressed on the major subsets of immune
2020-04-02
Because EBI2 is expressed on the major subsets of immune cells, and small molecule antagonists for EBI2 were recently described (Benned-Jensen et al., 2013, Gessier et al., 2014), EBI2 constitutes a tempting drug target reminiscent of the sphingosine-1-phosphate receptor superagonist fingolimod/Gile
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In contrast to SQLE HMGCR
2020-04-02
In contrast to SQLE, HMGCR could be efficiently degraded in ML-265 synthesis lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our re
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br Results br Discussion Many studies have shown
2020-04-02
Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific ARM1 type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous studies o
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As demonstrated by Mak and colleagues ER
2020-04-02
As demonstrated by Mak and colleagues, ERβ is known to be a part of the NFκB-HIF-1α signaling pathway during hypoxia as well as chronic inflammation of prostate (Mak et al., 2015), therefore in the next part of the study, we evaluated whether ZEA-induced ROS production is also associated with NFκB-H
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It is well established that p maintains
2020-04-02
It is well established that p53 maintains genomic integrity in response to a variety of cell stresses including DNA damage and oncogenic stress among others [6], [7], [8], [9]. p53 promotes the expression of several genes to cause SB-505124 hydrochloride arrest and to repair cellular damage. There
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Introduction Formate dehydrogenase enzymes FDHs are a
2020-04-01
Introduction Formate dehydrogenase enzymes (FDHs) are a group of heterogeneous proteins that catalyse the reversible formate () oxidation to carbon dioxide () (Eq. (1)). These enzymes are classified in two families, one gathering the enzymes that hold no redox-active centres and another that includ
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25-hydroxyvitamin d3 Group B phytocystatins are also express
2020-04-01
Group B phytocystatins are also expressed in caryopses. Although their expression patterns during germination are similar to those of the group A inhibitors, their expression patterns during seed development vary, indicating that they play different roles in the latter process. The highest levels of
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It is well established that a number of
2020-04-01
It is well established that a number of intracellular signaling pathways mediate sensitization of sensory neurons (Gold and Gebhart, 2010, Richardson and Vasko, 2002). This redundancy could be advantageous since it provides diversity in initiating and maintaining hypersensitivity in response to inju
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On the other hand the death
2020-03-31
On the other hand, the death domain is a conserved stretch of around 80AA which is commonly found in death receptor proteins, it play a major role in the interaction between other proteins. Also as a platform for the death-inducing signaling complex (DISC) formation (Chaigne-Delalande et al., 2008).
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In addition we investigated if
2020-03-31
In addition, we investigated if the previously reported papain inhibitor can inhibit rhodesain, and found that it was not active at inhibiting rhodesain. The vinyl sulfone analogue of () was then synthesized and tested, and it was also inactive towards rhodesain. We then determined the time depend
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Instead of receptor interaction or GT activity we focused on
2020-03-31
Instead of receptor interaction or GT activity, we focused on the CPD and autoprocessing. The CPDs from the 2 toxins are highly homologous: each cysteine protease targets an intramolecular substrate and mediates InsP6-induced autoprocessing to release the GTD into host cytosol.40, 41 However, TcdB i
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Previous studies revealed the expression of
2020-03-31
Previous studies revealed the expression of the CCR3 receptor in neurons and its neuroprotective function using mice lacking CCR3 expression (Wainwright et al., 2009). The regulation of CCR3 receptor expression in the microglia and astrocytes was shown in neurological disorders and has been demonstr
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Allele specific methylation has been observed in
2020-03-31
Allele-specific methylation has been observed in CpG islands of imprinted genes.27, 32 In the present study, however, methylation of CpG1 was specific to ALL 95 9 receptor and occurred in the leukemia cells of 28% of children with ALL, but it was not found in normal leukocytes from the same patients
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The mechanism underlying the increased PON levels found
2020-03-31
The mechanism underlying the increased PON1 levels found in greenhouse workers may be accounted for by an increased protein Fusidic Acid sodium salt following pesticide interaction with different nuclear receptors as also occurs with other chemicals, such as polyphenols and statins [28]. A number o
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Temafloxacin hydrochloride br Results and discussion The res
2020-03-31
Results and discussion The results and subgroup analysis of cholesterol and NCS from the both surveys are listed in Table 2 and shown in Fig. 1, A1 to E2. Common discussion Unlikely to the other NCS assays, a target value for cholesterol could be reported in the present survey. For NCS assays
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