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Changes in DAPK concentration or catalytic activity in respo
2020-08-04
Changes in DAPK concentration or catalytic activity in response to cerebral ischemia have not been reported. This knowledge is required for a complete understanding of the role of DAPK in ischemia, and for future investigations into the potential of DAPK as a therapeutic target for the treatment of
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br Significance Preclinical data indicate that tumor
2020-08-04
Significance Preclinical data indicate that tumor-associated macrophages (TAMs) represent an attractive therapeutic target as they represent key orchestrators of various tumor-promoting processes, such as escape of immune surveillance. Here, we report that treatment with an anti-CSF-1R antibody (
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Results obtained with the CRF receptor
2020-08-04
Results obtained with the CRF receptor antagonists provided evidence that physiological release of CRF and CRF-related peptides within the BNST during restraint modulates the tachycardia through activation of local CRF1 receptors while CRF2 receptors mediates the tail skin temperature responses. Mo
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More recently it was discovered that BChE hydrolyzes the
2020-08-04
More recently, it was discovered that BChE hydrolyzes the neuropeptide gut hormone, ghrelin [25], [26], [27], [28]. Nonetheless, because the enzyme reaction is very slow, those who first reported this finding were initially reluctant to attribute a real physiological role for that phenomenon. Our ow
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br Conclusions br Acknowledgements This work was financially
2020-08-04
Conclusions Acknowledgements This work was financially supported by the National Key Research and Development Program of China (grant 2016YFD0400301) and the Key Research and Development Program of Zhejiang Province (grant 2017C02015). Introduction A common complication of the kinetics of
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br Concluding Remarks Recent studies have provided
2020-08-04
Concluding Remarks Recent studies have provided unprecedented details of APC/C structure and enzymology, which explain how the activity of this massive E3 ligase is controlled, and how ubiquitylation is achieved to temporally regulate cell division. Although one pervasive question has been why th
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br Materials and methods br Results br
2020-08-04
Materials and methods Results Discussion TCA can induce the cell proliferation and prevention of apoptosis in mice [19]. However, Our study showed that TCA could not induce the cell proliferation directly, which might be associated with the complicated environment in vivo. TCA treated cells
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DNA methylation is associated with transcriptional silencing
2020-08-04
DNA methylation is associated with transcriptional silencing of tumor suppressors or other genes important for normal cellular function and plays an important role in the development of cancer and other diseases (such as breast and colorectal cancers) [19]. DNA methyltransferases (MTases) are a fami
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In Lan Ma et al coupled the
2020-08-03
In 2013, Lan Ma et al. coupled the CPA EoS with two-step hydrate formation Calpain Inhibitor II, ALLM for predicting hydrate formation equilibrium conditions of hydrogen-containing systems. Their system included H2, CH4, C2H4, C2H6, C3H8 and tetrahydrofuran (THF). They substituted the SRK term of C
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Using a large cohort of Han Chinese adults and based
2020-08-03
Using a large cohort of Han Chinese adults and based on a genotype-endophenotype-phenotype pathway model, the current study, adjusting for the relevant confounding factors, aimed to test whether functional COMT Val158Met polymorphism has an age-specific correlation with decreased parasympathetically
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br Materials and methods br Results and discussion
2020-08-03
Materials and methods Results and discussion Discussion and conclusion TERRA G-quadruplexes are ideal therapeutic targets because they are required for telomere heterochromatin formation in all cancer cells, even in those that do not require telomerase (ALT-positive tumors). Several TERRA-b
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To overcome the previously mentioned limitations
2020-08-03
To overcome the previously mentioned limitations of RT-PCR and FISH, we sought to develop a next-generation sequencing (NGS)–based method for the molecular diagnosis of fusion-associated childhood sarcomas. Herein, we present a novel multiplex assay, designated ChildSeq-RNA, which combines target-ca
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br Introd http www apexbt com media diy images wb
2020-08-03
Introduction Blood vessels form via two distinct processes, vasculogenesis and angiogenesis [1], [2]. Vasculogenesis involves in the differentiation of endothelial cells (ECs) from mesodermal angioblasts, which differentiate into endothelial cords [3]. In the angiogenesis, new blood vessels arise
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Most studies to date have been unable
2020-08-03
Most studies to date have been unable to provide sufficient evidence to support the use of CYP450 Rucaparib free base australia testing to improve therapeutic efficacy in the use of antipsychotic medications and the clinical utility of this strategy has not been determined. The inability to conclusi
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To avoid the difficulty of
2020-07-31
To avoid the difficulty of the nonsmooth constraints, a sequence of smooth problems by using smoothing functions have been progressively approximated this nonsmooth problem. To date, there have been many smoothing functions, such as perturbed Fischer–Burmeister (FB), Chen–Harker–Kanzow–Smale (CHKS),
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