• Here we studied GLUT targeted nanomedicines as a new

  2021-10-09

  

  Here, we studied GLUT1-targeted nanomedicines as a new strategy directed to overcome vascular barrier, enhancing delivery and efficacy in solid tumors. These nanomedicines were prepared by controlled installation of glucose on polymeric micelles incorporating the antitumor agent cisplatin, which is

• br Acknowledgements This work was supported by the National

  2021-10-09

  

  Acknowledgements This work was supported by the National Institutes of Health [grant number GM024417]. Introduction In mammals, glucose is the major energy substrate supporting conceptus development after BAMB-4 formation [1,2]. While the equine morula uses similar amounts of pyruvate and gl

• In single channel studies Zn

  2021-10-08

  

  In single channel studies, Zn2+ primarily inhibits GABA-A receptors through the reduction of channel opening probability (Smart, 1992, Smart et al., 1994). In slice recordings, Zn2+ significantly reduces phasic mIPSC event amplitude and kinetics, as well as desensitization kinetics (Barberis et al.,

• In addition to the importance of heme as

  2021-10-08

  

  In addition to the importance of heme as an enzymatic cofactor, heme also acts as an important iron source. In order to access the iron within heme, S. aureus encodes heme degrading enzymes known as heme oxygenases (Skaar et al., 2004b; Wu et al., 2005). The two heme oxygenases encoded by S. aureus,

• Significan http www apexbt com media

  2021-10-08

  

  Significant DNA damage was observed in hemolymph of molluscs exposed to raw composite tannery effluent as evident from comet assay images. DNA damage was evaluated by the presence of tail resembling that of comet in single strand DNA. Break in DNA strand was reported in the liver and gill l-ascorbic

• Because of its excellent GPR potency good hERG

  2021-10-08

  

  Because of its excellent GPR119 potency, good hERG selectivity and favorable rat t, hbv virus was scaled-up and further profiled. The synthetic protocols described in , were both suitable for a multi-gram scale synthesis of compound . An off-target screen was performed against an extensive panel

• Galanthamine Finally we investigated increasing basicity as

  2021-10-08

  

  Finally, we investigated increasing basicity as a way to improve solubility. We expected that conversion of the ether linkage of to an -methyl group could improve solubility. More than expected, Galanthamine demonstrated significant improvement of values of solubility for the two media, especially f

• br Niacin has long been

  2021-10-08

  

  Niacin () () has long been used for the treatment of lipid disorders and for the prevention of cardiovascular disease, the leading cause of death in the U.S., as a result of its ability to raise high-density lipoprotein (HDL) levels. Recent mechanistic investigations have shown that niacin may exe

• br Flavonoid function Antioxidants are

  2021-10-08

  

  Flavonoid function Antioxidants are compounds - when present at a lower concentration compared oxidizable substrate - that delay or prevent oxidation of the substrate [14], [106]. Antioxidants act as nucleophiles to reduce an oxidative molecule to prevent its interaction with another molecule [14

• The mechanism underlying the anorectic effect of OXM is

  2021-10-08

  

  The mechanism underlying the anorectic effect of OXM is well established. It is centrally mediated via GLP-1 receptor activation, confirmed by both pharmacological blockade of the GLP-1 receptor, and using GLP-1 receptor knock-out mice [2], [11], [12]. However, the mechanism by which it increases en

• ML 239 mg br During cardiac ischaemia a

  2021-10-08

  

  During cardiac ischaemia, a decrease in GJ coupling is observed, which results in slower conduction of electrical impulses and a higher risk of arrhythmias.[13], [20] In Huntington’s disease an increase in the ML 239 mg of 5 Cxs was observed in the astrocytes in the brain, suggesting an adaptive

• DNAzymes a series of nucleotide sequences

  2021-10-07

  

  DNAzymes, a series of nucleotide sequences with specific catalytic activity, have been reported frequently applied in detection assays for such as ions and amino acids, due to the advantage in stability, high cost-effectiveness and modification convenience, by comparison with protein enzymes. The DN

• br Results br Discussion Our studies highlight MUFAs as key

  2021-10-07

  

  Results Discussion Our studies highlight MUFAs as key lipid modulators of both non-apoptotic and apoptotic cell death. Recent studies show that a more mesenchymal phenotype, de-differentiation, and acquired resistance to targeted inhibitors, can all promote a ferroptosis-sensitive cell state (

• Recently the classical view of

  2021-10-07

  

  Recently, the classical view of the compartmentalization of the plant isoprenoid metabolism has been re-evaluated, following the demonstration of the partial peroxisomal localization of the mevalonic Propidium iodide (MVA) pathway, generally regarded as cytosolic. Using GFP-tagging approaches, the

• Recently the classical view of

  2021-10-07

  

  Recently, the classical view of the compartmentalization of the plant isoprenoid metabolism has been re-evaluated, following the demonstration of the partial peroxisomal localization of the mevalonic Streptomycin sulfate (MVA) pathway, generally regarded as cytosolic. Using GFP-tagging approaches,

14358 records 542/958 page Previous Next First page 上5页 541542543544545 下5页 Last page