• The present study chose the fdh gene

  2021-10-29

  

  The present study chose the fdh gene, the homolog of mammalian GSNOR, to generate UAS-fdh and fdh double-stranded RNA interference (ds-RNAi) transgenic Drosophila. These transgenic models were used to study the effect of GSNOR activity modulation on visual learning and memory and to explore the poss

• br Regulation of Glu transporters The pivotal role

  2021-10-29

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino 69 8 australia calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These include transc

• This GluR A independent mechanism by

  2021-10-29

  

  This GluR-A-independent mechanism, by which the associative strength of spatial locations can be increased (and/or decreased) gradually over many trials, and which presumably underlies spatial reference memory acquisition during tasks such as the Morris watermaze or the radial maze (Zamanillo et al.

• Since the late s synthetic GC e g prednisone

  2021-10-29

  

  Since the late 1940s, synthetic GC (e.g. prednisone, prednisolone, dexamethasone) have been used extensively in the treatment of chronic inflammatory conditions such as rheumatoid arthritis and asthma, and for their immunosuppressant action in preventing organ rejection post transplantation. Cortico

• Medulloblastoma predominantly occurs in infants and children

  2021-10-29

  

  Medulloblastoma predominantly occurs in infants and children, and is the most-common type of paediatric malignant c-kit inhibitor tumour, accounting for about 20% of all childhood brain tumors [63]. According to cancer genomics, medulloblastoma consists of at least 4 distinct subgroups: Hh driven, W

• The widespread involvement of HH GLI in

  2021-10-29

  

  The widespread involvement of HH/GLI in human malignancies has initiated a remarkable effort to identify selective HPIs. As shown in Table 2.1, most of these small molecule inhibitors target the essential effector protein SMO, which should lead to pathway abrogation by eventually decreasing the GLIA

• suramin Recently several studies addressed cytological and b

  2021-10-29

  

  Recently, several studies addressed cytological and biochemical features of oocyte aging. It was reported that cytological changes associated with the mammalian post-ovulatory oocyte aging include chromatin disorganization, abnormal meiotic spindle location or its disruption, partial exocytosis of c

• br Materials and methods br Results and

  2021-10-29

  

  Materials and methods Results and discussion Conclusions Acknowledgements This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684), and also by t

• Type II diabetes is characterized

  2021-10-29

  

  Type II diabetes is characterized by an inability to maintain glucose homeostasis due to insulin desensitization and/or insufficient insulin secretion. GPR40, also known as free fatty Letermovir receptor 1 (FFAR1), is a member of the G-protein-coupled lipid-activated family of receptors and is prima

• At the heart of ferroptosis

  2021-10-29

  

  At the heart of ferroptosis is a process of lethal lipid peroxidation, which is the oxidative addition of molecular oxygen (O2) to lipids, such as polyunsaturated fatty acyl tails in phospholipids. The first descriptions of such enzymatic reactions were in 1955 by Peterson and colleagues [50] and Ro

• Here we show in contrast to previous work that several

  2021-10-29

  

  Here we show, in contrast to previous work, that several phenotypes associated with Orb6 inactivation, including increased cell width, are independent of Gef1. We further find that Orb6 positively regulates exocytosis, also independently of Gef1. To identify novel targets of Orb6, we performed quant

• Hyperhomocysteinemia HHcy is a clinical condition characteri

  2021-10-29

  

  Hyperhomocysteinemia (HHcy) is a clinical condition characterized by increased levels of plasma homocysteine (Hcy) and a well-known risk factor for CVDs. Hcy is a sulfur-containing non-protein amino XMD17-109 formed during the intracellular conversion of methionine to cysteine. Previous study demon

• Nevertheless the frequency of CTCs was higher in patients

  2021-10-29

  

  Nevertheless, the frequency of CTCs was higher in patients with metastatic breast cancer, which is to be expected because cancer MK-8245 from the original clone that caused the metastasis probably had features favoring their spread throughout the body. When we take HER2+ CTC counts ≥ 3 as a “strong

• Afuresertib The difference in the expression of

  2021-10-28

  

  The difference in the expression of functional FFARs between neutrophils and monocytes/macrophages suggests that the role of FFA2R may be restricted to the very early phase of acute inflammation where neutrophils are dominating players called into action, whereas GPR84 may have a broader functional

• br Materials and methods br Results br Discussion

  2021-10-28

  

  Materials and methods Results Discussion To understand the molecular basis for how ghrelin secretion is regulated at the cellular level, we identified the full repertoire of 7TM receptors and G proteins in gastric ghrelin 7ACC1 and functionally characterized the majority of the receptors w

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