• br Competing interests br Authors contributions br Transpare

  2022-09-01

  

  Competing interests Authors contributions Transparency document Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver diseases ranging from simple steatosis to non-alcoholic steatohepatitis (NASH), which may further progress to liver cirrhosis and liver carcinoma

• The canonical tumor suppressor p

  2022-09-01

  

  The canonical tumor suppressor p53 has also been implicated as a transcriptional mediator of ferroptotic death (Jiang et al., 2015, Tarangelo et al., 2018, Wang et al., 2016, Xie et al., 2017). Specifically, p53 negatively regulates transcription of SLC7A11, the cystine-glutamate antiporter (Xc-) (J

• AD is a major neurological disorder usually effecting

  2022-09-01

  

  AD is a major neurological disorder, usually effecting the elderly population, which is difficult to diagnose until symptoms begin to accumulate. As of 2013, approximately five million Americans were living with AD. The number with this disease is projected to be 16 million by 2050 (Hebert et al., 2

• While histone modifications can alter inter nucleosomal inte

  2022-08-31

  

  While histone modifications can alter inter-nucleosomal interactions that govern the compaction state of a chromatin fiber (Francis et al., 2004, Kalashnikova et al., 2013, Lu et al., 2008), the potential impact of histone modifications on higher-order chromosome organization beyond chromatin-fiber 

• Here we dissect X chromosome

  2022-08-31

  

  Here, we dissect X chromosome dosage compensation (DC) in C. elegans to determine the effect of chromatin modifications on higher-order chromosome structure during long-range gene regulation. DC is exemplary because it controls hundreds of genes simultaneously, it distinguishes X chromosomes from au

• br Conclusion Our data allow

  2022-08-31

  

  Conclusion Our data allow pharmacological discrimination of diverse of H3 Harringtonine antagonists that can be linked to their differential efficacy in preclinical and clinical disease settings (Fig. 6). Moreover, we identify the sigma-1 receptor as a common “off target” for H3 antagonists, and

• One class of microbial derived metabolites that

  2022-08-31

  

  One class of microbial-derived metabolites that have received significant attention are the short-chain fatty acids (SCFA), which include butyrate, acetate and propionate. The production of SCFA occurs in the colon following microbial fermentation of dietary fibers and SCFA can also be consumed in c

• Biochemical assays have provided evidence that prolonged exp

  2022-08-31

  

  Biochemical assays have provided evidence that prolonged exposure to GPR35 agonists can induce GPR35 internalization [2], [4], [11], [13]. Our finding that neuronal excitability decreased regardless of whether the slices were superfused for a few minutes or incubated for a few hours with GPR35 agoni

• Wasting syndrome is a common complication of

  2022-08-30

  

  Wasting syndrome is a common complication of HIV infection and is marked by progressive weight loss and weakness, often associated with fever (Weinroth et al., 1995). Fever is a highly complex process initiated by the action on the Deoxycholic acid thermosensitive cells of a number of endogenous py

• FFAR is highly expressed not only in

  2022-08-29

  

  FFAR1 is highly expressed not only in β cells but also in α Apatinib sale (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with the many other i

• Type diabetes mellitus is characterised

  2022-08-29

  

  Type 2 diabetes mellitus is characterised by two major features: peripheral insulin resistance and impaired insulin secretion from pancreatic beta folate analogue [1]. The condition occurs when the pancreatic beta cells are unable to compensate for increased insulin demand due to insulin resistance

• In the small intestine digestion and

  2022-08-29

  

  In the small intestine, digestion and cyclic adenosine monophosphate of the nutrients are the next processes with an impact on the resulting plasma profile. Normally, neither carbohydrate digestion nor absorption are limiting factors, which is illustrated by the rapid and extensive absorption of gl

• Gastric inhibitory polypeptide a hormone belonging

  2022-08-29

  

  Gastric inhibitory polypeptide, a hormone belonging to the glucagon-secretin family of peptides, exhibits protection against the neurodegeneration and also stimulates neurogenesis in adult rats in a paracrine manner (Gault and Holscher, 2008, Nyberg et al., 2005, Usdin et al., 1993). The expression

• Some malignant human tumors cells also express FPRs

  2022-08-29

  

  Some malignant human tumors SNDX275 also express FPRs and respond to bacterial or endogenous agonists by increased motility and growth. For instance, FPRs expressed by human gastric cancer cells, mediate epithelial–mesenchymal transition, cell proliferation, migration, and resistance to apoptosis [

• Considering the conformational preferences of the

  2022-08-29

  

  Considering the conformational preferences of the SRSRY sequence in the x-ray structures of soluble uPAR (SuPAR) [18], [19], [20], [50], [51], it is included in a quite flexible linker delimited by Cys76 and Cys95 residues. The SRSRY sequence adopts either α-turned or β-extended conformation. In any

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